SYNTHESIS OF METHYL CELLULOSE FROM CELLULOSE AS A RESULT OF ISOLATION FROM SIWALAN FRUIT FIBER (Borassus flabellifer L.) AND ITS APPLICATIONS IN TRANSDERMAL PATCH PREPARATIONS OF DICLOFENAC SODIUM MATRIX TYPE

Sentot Purwandi

Methyl cellulose is raw material that widely used in the pharmaceutical industry as additional ingredient, including polymer of patch. In this research, synthesis of methyl cellulose derived from cellulose as result of isolation from siwalan (Borassus flabellifer L.) rind fibres. The aim of this study to determine characteristics methyl cellulose that will assess through USP 44 and the product marketed as a comparison. Organoleptic, moisture content, pH, Fourier Transform-Infra Red, X-Ray Diffraction, Differential Scanning Calorimetry and Scanning Electron Microscope analysis were used to assess the cellulose and methyl cellulose. The characterization result showed the cellulose and methyl cellulose had the pH and moisture content met the specification. The Fourier Transform-Infra Red showed absorption for O-H, C-H, C-O-H, C-O, and -glycosidic which typical cellulose and methyl cellulose peaks. The characterization showing identical results by organoleptic, moisture content, functional groups, and crystallinity. The different results were obtained for the morphological and melting point tests. It can be concluded that the synthesis of methyl cellulose from cellulose as a result of isolation of Borassus flabellifer L. rind fibres was successfully carried out with the best ratio between cellulose - methylene chloride of 1:12. The patch formulation of the use of methyl cellulose has been carried out in this study to prove that methyl cellulose synthesised can be used as pharmaceutical raw materials. The optimum diclofenac sodium patch formula was successfully carried out at a ratio of methyl cellulose and PVP K-30 of 1:3. Physical characteristics are carried out to prove that a good patch is obtained including moisture content, thickness, and content of active ingredients. Characterization of diclofenac sodium patch showed identical results with the comparison. The suggestion on the research is to carry out on the effectiveness of methyl cellulose polymer study by in vivo testing on diclofenac sodium patch. Standardized and validated process of synthesis and isolating methyl cellulose and cellulose from siwalan rind fibres,

Keywords: Borassus flabellifer L, Isolation Cellulose, Synthesis methyl cellulose, Characterization, patch natrium diclofenac