The research aimed to determine the metabolite profile of the essential oil of Cinnamomum burmannii (Nees & T.Nees) Blume bark (C. burmannii bark oil) which has the potential as anti-inflammatory from 5 regions of Indonesia.

This study reports standardization of the bark of C. burmannii, analysis of the metabolite profile of the essential  oil of the bark of C.  burmannii,  analysis of the composition of secondary metabolites using GC-MS, in vivo testing of anti• inflammatory effects using the paw test technique on Wistar rats with doses of 30,  60 and 90 mg/kg BW as well as the anti-inflammatory effect of essential oils from 5 regions in  Indonesia  with  a  dose  of 60  mg/kg  BW  with  indicators  of edema  inhibition percentage,  number of inflammatory cells and TNF-a expression.  Finally,  an in silica test was carried out on the metabolite compounds. The results of this study indicate that the essential  oil of the bark of C.  burmanii  from 5 regions  in Indonesia  has anti• inflammatory properties. The best is essential oil  from Kerinci and Lombok Timur. Trans-Cinnamaldehyde  can be used as an analytical marker because it  was found in quite large amounts in all essential oils from 5 regions.

The results of the screening of metabolites that are predicted to have anti• inflammatory properties with molecular docking techniques namely: y-Muurolene, a• Terpineol, trans-Cinnamaldehyde, Copaene, trans-a-Bergamotene, Caryophylene, a• Muurulene, Caryophyllene oxide, D-Limonene, a-Pinene, Bornyl acetate and Linalool. Molecular  docking  with the target  protein COX-1  a-Terpineol  and with the target protein COX-2 y-Muurolene have the lowest binding affinity.